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Cognidine®

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Cognidine®

Alimento complementario a base de  levaduras (Saccharomyces cerevisae), fosfato tricálcico, harina de krill, almidón de patata, estearato de magnesio, cristobalita, pulpa de manzana seca, manitol.

Species
Product Description
  • Chicken protein-free
  • Without preservatives.
  • No artificial colorings
  • Suitable modes of use according to the weight of the pet
  • Easily divisible tablets.

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Chicken protein-free
Without preservatives.
Easily divisible tablets.
Easily divisible tablets.

Uridina1,2

Dried apple pulp

Tryptophan5,6

Biotin

Selenium and Zinc

Barley bran

Cognidine®

Box with 60 tablets, in blister packs of 10 tablets each.

Box with 60 tablets, in blister packs of 10 tablets each.

 Cat

1 tablet per day.

Dog
  • Up to 10 kg: 1 tablet per day.
  • 10 to 20 kg: 2 tablets per day.
  • 20 to 30 kg: 3 tablets per day.
  • 30 to 40 kg: 4 tablets per day.
  • Over 40 kg: 5 tablets per day.
Other indications

Oral route

If preferred, mix with the usual food.

As it is a dietary supplement, it can be administered continuously.

Ingredients

Uridina1,2

Dried apple pulp

Tryptophan5,6

Biotin

Selenium and Zinc

Barley bran

Presentation

Cognidine®

Box with 60 tablets, in blister packs of 10 tablets each.

Box with 60 tablets, in blister packs of 10 tablets each.

What are the instructions for use?

 Cat

1 tablet per day.

Dog
  • Up to 10 kg: 1 tablet per day.
  • 10 to 20 kg: 2 tablets per day.
  • 20 to 30 kg: 3 tablets per day.
  • 30 to 40 kg: 4 tablets per day.
  • Over 40 kg: 5 tablets per day.
Other indications

Oral route

If preferred, mix with the usual food.

As it is a dietary supplement, it can be administered continuously.

Cognitive Dysfunction in Dogs and Cats

Cognitive Dysfunction Syndrome (CDS) in cats and dogs is a clinical condition that affects older pets, characterized by a series of neurological disorders that negatively impact their cognitive functions, changes in behavior, social interactions, and quality of life.

Clinical signs include:

  • Changes in interaction with owners or other animals.
  • Disorientation and confusion, anxiety, and restlessness.
  • Sleep-wake cycle disorders, changes in behavior patterns.
  • Alterations in daily routines.
  • Changes in motor function.

CDS has become an increasingly important area of research and veterinary care. Early diagnosis and appropriate intervention are key to addressing this syndrome.

Factors Associated with Cognitive Dysfunction Syndrome in Dogs and Cats

CDS manifests in various ways:

  • Macroscopic changes in the brain: cortical atrophy, which affects areas of the brain related to memory and learning, as well as the hippocampus, a structure that contributes to the formation of new memories.
  • Neuronal changes: such as the loss of nerve cells in key brain areas.
  • Oxidative damage and inflammation: leading to the deterioration of proteins, lipids, and nucleotides in the brain, eventually resulting in neuron death.
  • Accumulation of ß-amyloid protein: may contribute to neuronal loss and brain atrophy.

CDS can also result from cerebrovascular pathologies: cerebral vascular changes, gliosis, and ventricular dilation, leading to cerebral atrophy, ventricular enlargement, and lesions in the medial temporal lobes.

Consult your veterinarian

"At Pharmadiet, we encourage all pet owners to maintain a close relationship with their trusted veterinarian.

Regular consultations with veterinary professionals are fundamental for preventive care, early diagnosis of health problems, and planning appropriate treatments.

Through our close collaboration with these experts, we work together to keep your animal companions in their best health, ensuring a full and active life for them."

References

  1. Wattig B et al. Acceleration of nerve and muscle regeneration by administration of nucleotides–electroneurophysiological and morphometrical investigations. Acta Histochem Suppl. 1992;42:333-9.
  2. Chen TH et al. A nucleoside-nucleotide mixture may reduce memory deterioration in old senescence-accelerated mice. . J Nutr. 2000 Dec;130(12):3085-9.
  3. Harris CB. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects.1. J Nutr Biochem. 2013 Dec;24(12):2076-84.
  4. He B. Effects of pyrroloquinoline quinine on oxidative stress- induced apoptosis of Schwann cells and its mechanism. Zhonghua Zheng Xing Wai Ke Za Zhi. 2014 Mar;30(2):111-7
  5. Silber BY. Effects of tryptophan loading on human cognition, mood, and sleep. Neuroscience and Biobehavioral Reviews .2010; 34: 387–407.
  6. Jean S. DeNapoli. Effect of dietary protein content and tryptophan supplementation on dominance aggression, territorial aggression, and hyperactivity in dogs. 2000; JAVMA, Vol 217, No. 4.
  7. Murphy T, et al. Effects of diet on brain plasticity in animal and human Studies: mind the gap. Neural Plasticity.2014; ID 563160.

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